Modifications

Nataf est co-auteur avec Mark Geier d'une étude publiée en 2008 dans Journal of the Neurological Sciences (JNS-10672; No of Pages 8). L'adresse du journal : Mark R. Geier, 14 Redgate Ct., Silver Spring, MD 20905. Cette étude a été signalée, commentée et saluée dans les pages en français d'Autism Treatment Institute<ref>http://www.autism.com/trans_french_ARRIV22No32008mercury</ref>.

Nataf est co-auteur avec Mark Geier d'une étude publiée en 2008 dans Journal of the Neurological Sciences (JNS-10672; No of Pages 8). L'adresse du journal : Mark R. Geier, 14 Redgate Ct., Silver Spring, MD 20905. Cette étude a été signalée, commentée et saluée dans les pages en français d'Autism Treatment Institute<ref>http://www.autism.com/trans_french_ARRIV22No32008mercury</ref>.

Ici, le détail de l'étude<ref>http://webcache.googleusercontent.com/search?q=cache:ySEHsBmqMngJ:www.drd411.com/storage/documents/Biomarkers_of_Environmental_Toxicity__Susceptibilty_in_Autism_In_Press1.pdf+&cd=7&hl=fr&ct=clnk&gl=fr Le document a été supprimé, il n'en reste plus que le cache.</ref>: <br>Journal of the Neurological Sciences<br>Biomarkers of environmental toxicity and susceptibility in autism<br>David A. Geier a,b, Janet K. Kern c,d, Carolyn R. Garver c, James B. Adams e, Tapan Audhya f,Robert Nataf g, Mark R. Geier h<br> - a Institute of Chronic Illnesses, Inc., Silver Spring, Maryland, USA<br> - b CoMeD, Inc., Silver Spring, Maryland, USA<br> - c Autism Treatment Center, Dallas, Texas, USA<br> - d University of Texas Southwestern Medical Center, Dallas, Texas, USA<br> - e Arizona State University, Tempe, Arizona, USA<br> - f Vitamin Diagnostics, Cliffwood Beach, New Jersey, USA<br> - g Laboratoire Philippe Auguste, Paris, France<br> - h The Genetic Centers of America, Silver Spring, Maryland, USA<br><br>Article history:Received 21 May 2008. Received in revised form 11 August 2008. Accepted 15 August 2008. Available online xxxx<br><br> Abstract: Autism spectrum disorders (ASDs) may result from a combination of genetic/biochemical susceptibilities inthe form of a reduced ability to excrete mercury and/or increased environmental exposure at keydevelopmental times. Urinary porphyrins and transsulfuration metabolites in participants diagnosed with anASD were examined. A prospective, blinded study was undertaken to evaluate a cohort of 28 participantswith an ASD diagnosis for Childhood Autism Rating Scale (CARS) scores, urinary porphyrins, andtranssulfuration metabolites. Testing was conducted using Vitamin Diagnostics, Inc. (CLIA-approved) and Laboratoire Philippe Auguste (ISO-approved). Participants with severe ASDs had significantly increasedmercury intoxication-associated urinary porphyrins (pentacarboxyporphyrin, precoproporphyrin, andcoproporphyrin) in comparison to participants with mild ASDs, whereas other urinary porphyrins weresimilar in both groups. Significantly decreased plasma levels of reduced glutathione (GSH), cysteine, andsulfate were observed among study participants relative to controls. In contrast, study participants hadsignificantly increased plasma oxidized glutathione (GSSG) relative to controls. Mercury intoxication-associated urinary porphyrins were significantly correlated with increasing CARS scores and GSSG levels,whereas other urinary porphyrins did not show these relationships. The urinary porphyrin and CARS scorecorrelations observed among study participants suggest that mercury intoxication is significantly associatedwith autistic symptoms. The transsulfuration abnormalities observed among study participants indicate thatmercury intoxication was associated with increased oxidative stress and decreased detoxification capacity.<br><br>☆ Study Funding: This research was funded by a grant from the Autism Research Institute, the non-profit CoMeD, Inc., and by the non-profit Institute of Chronic Illnesses,Inc. through a grant from the Brenen Hornstein Autism Research & Education (BHARE)Foundation. Potential Conflicts of Interest: David Geier, Janet Kern, James Adams, andMark Geier have been involved in vaccine/biologic litigation. Robert Nataf and TapanAudhya are affiliated with the labs used to test the study participants.

Ici, le détail de l'étude<ref>http://webcache.googleusercontent.com/search?q=cache:ySEHsBmqMngJ:www.drd411.com/storage/documents/Biomarkers_of_Environmental_Toxicity__Susceptibilty_in_Autism_In_Press1.pdf+&cd=7&hl=fr&ct=clnk&gl=fr Le document a été supprimé, il n'en reste plus que le cache.</ref>: <br>Journal of the Neurological Sciences<br>Biomarkers of environmental toxicity and susceptibility in autism<br>David A. Geier a,b, Janet K. Kern c,d, Carolyn R. Garver c, James B. Adams e, Tapan Audhya f,Robert Nataf g, Mark R. Geier h<br> - a Institute of Chronic Illnesses, Inc., Silver Spring, Maryland, USA<br> - b CoMeD, Inc., Silver Spring, Maryland, USA<br> - c Autism Treatment Center, Dallas, Texas, USA<br> - d University of Texas Southwestern Medical Center, Dallas, Texas, USA<br> - e Arizona State University, Tempe, Arizona, USA<br> - f Vitamin Diagnostics, Cliffwood Beach, New Jersey, USA<br> - g Laboratoire Philippe Auguste, Paris, France<br> - h The Genetic Centers of America, Silver Spring, Maryland, USA<br><br>Article history:Received 21 May 2008. Received in revised form 11 August 2008. Accepted 15 August 2008. Available online xxxx<br><br> Abstract: Autism spectrum disorders (ASDs) may result from a combination of genetic/biochemical susceptibilities inthe form of a reduced ability to excrete mercury and/or increased environmental exposure at keydevelopmental times. Urinary porphyrins and transsulfuration metabolites in participants diagnosed with anASD were examined. A prospective, blinded study was undertaken to evaluate a cohort of 28 participantswith an ASD diagnosis for Childhood Autism Rating Scale (CARS) scores, urinary porphyrins, andtranssulfuration metabolites. Testing was conducted using Vitamin Diagnostics, Inc. (CLIA-approved) and Laboratoire Philippe Auguste (ISO-approved). Participants with severe ASDs had significantly increasedmercury intoxication-associated urinary porphyrins (pentacarboxyporphyrin, precoproporphyrin, andcoproporphyrin) in comparison to participants with mild ASDs, whereas other urinary porphyrins weresimilar in both groups. Significantly decreased plasma levels of reduced glutathione (GSH), cysteine, andsulfate were observed among study participants relative to controls. In contrast, study participants hadsignificantly increased plasma oxidized glutathione (GSSG) relative to controls. Mercury intoxication-associated urinary porphyrins were significantly correlated with increasing CARS scores and GSSG levels,whereas other urinary porphyrins did not show these relationships. The urinary porphyrin and CARS scorecorrelations observed among study participants suggest that mercury intoxication is significantly associatedwith autistic symptoms. The transsulfuration abnormalities observed among study participants indicate thatmercury intoxication was associated with increased oxidative stress and decreased detoxification capacity.<br><br>☆ Study Funding: This research was funded by a grant from the Autism Research Institute, the non-profit CoMeD, Inc., and by the non-profit Institute of Chronic Illnesses,Inc. through a grant from the Brenen Hornstein Autism Research & Education (BHARE)Foundation. Potential Conflicts of Interest: David Geier, Janet Kern, James Adams, and Mark Geier have been involved in vaccine/biologic litigation. Robert Nataf and TapanAudhya are affiliated with the labs used to test the study participants.

Depuis, Mark Geier s'est vu retirer son autorisation d'exercer dans presque la totalité des états des USA<ref>http://www.stltoday.com/news/local/metro/controversial-autism-doctor-loses-license-elsewhere-but-can-still-practice/article_3dd4aac0-675f-5998-84f3-beb29468d36b.html?utm_medium=twitter&utm_source=twitterfeed Controversial autism doctor loses license elsewhere, but can still practice in Missouri, Illinois Publié le 04/10/2013 (anglais)</ref>.

Depuis, Mark Geier s'est vu retirer son autorisation d'exercer dans presque la totalité des états des USA<ref>http://www.stltoday.com/news/local/metro/controversial-autism-doctor-loses-license-elsewhere-but-can-still-practice/article_3dd4aac0-675f-5998-84f3-beb29468d36b.html?utm_medium=twitter&utm_source=twitterfeed Controversial autism doctor loses license elsewhere, but can still practice in Missouri, Illinois Publié le 04/10/2013 (anglais)</ref>.