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In 1835, the first double-blind drug study took place. The same year, Georg Löhner, a theologian and editor, published test results which he had obtained in cooperation with physicians, pharmacists, and further dignitaries in the town of Nuremberg. They examined 55 volunteers and did not establish any effect of homoeopathic dilution. This publication was met with fierce and polemic resistance by homoeopathic magazines of that time, e.g. by "Hygea - central organ for the homoeopathic or specific art of healing".

In 1835, the first double-blind drug study took place. The same year, Georg Löhner, a theologian and editor, published test results which he had obtained in cooperation with physicians, pharmacists, and further dignitaries in the town of Nuremberg. They examined 55 volunteers and did not establish any effect of homoeopathic dilution. This publication was met with fierce and polemic resistance by homoeopathic magazines of that time, e.g. by "Hygea - central organ for the homoeopathic or specific art of healing".

===The homoeopathy studies in the time of the National Socialism===

===Homoeopathy studies in the time of National Socialism===

Further studies of homoeopathy took place in the times of National Socialism. The regime intended a reorientation of public health care, the "new German medicine". Additionally, National Socialist circles voiced increasing criticisms of what they perceived as "Jewish medicine". Be

Further studies of homoeopathy took place in the times of National Socialism. The regime intended a reorientation of public health care, the "new German medicine". Additionally, National Socialist circles voiced increasing criticisms of what they perceived as "Jewish medicine". Drug studies were done at different homoeopathic hospitals by the state health office (Reichsgesundheitsamt - RGA) between 1936 and 1939, much of them placebo checked.  

Drug studies were done at different homoeopathic hospitals by the state health office (Reichsgesundheitsamt - RGA) between 1936 and 1939, much of them placebo checked.  

Above all the reliability of earlier medicine examinations and thus also the priority of the "pharmacological picture" developing on them should be investigated. The homoeopath Hanns Rabe (1890 - 1959), the internist Werner Siebert (1897 - 1951) and the pharmacology professors Gustav Kuschinsky (1904 - 1992) and Richard Bonsmann belonged to the study group. At that time the doctor and homoeopath Fritz Donner (1896 - 1979) who was working in Berlin at the homoeopathic department of the Rudolf Virchow hospital, was involved substantially at these checks too. Extensive notes from Donner about the RGA examinations and previous studies became known as Donner report for the homoeopathy and are available today in the original in the "homoeopathy archives" of the institute for history of the medicine of the Robert Bosch foundation in Stuttgart. But nothing positive for the homoeopathy came of the government-supported examinations. Double blinded experiments were carried out with Silicea C30, for example. The result: Verum and placebo caused equal much symptoms. It was not possible for the homoeopaths present to distinguish verum and placebo. In 1938/39 clinical attempts with homeopathics were also accomplished with negative results in the Robert Koch hospital in Berlin. The homoeopath Rabe reacted with the assumption that [...] homoeopathy is no pharmacotherapeutic method, as assumed till now, but a form of psychotherapy [...]. Fritz Donner in a memory protocol: Truthfully one would have to answer that during the medicine examination nothing came out and that a reaction speaking for a therapeutical effect of the used medicines never has occurred in the clinical tests with a patient. Nevertheless it was announced officially that certain difficulties would have manifested themselves so that one must start newly. The war prevented however further research. Donner expressed himself more considerably later within the 1960s: He called the examination a total fiasco for the homoeopathy.

Above all the reliability of earlier medicine examinations and thus also the priority of the "pharmacological picture" developing on them should be investigated. The homoeopath Hanns Rabe (1890 - 1959), the internist Werner Siebert (1897 - 1951) and the pharmacology professors Gustav Kuschinsky (1904 - 1992) and Richard Bonsmann belonged to the study group. At that time the doctor and homoeopath Fritz Donner (1896 - 1979) who was working in Berlin at the homoeopathic department of the Rudolf Virchow hospital, was involved substantially at these checks too. Extensive notes from Donner about the RGA examinations and previous studies became known as Donner report for the homoeopathy and are available today in the original in the "homoeopathy archives" of the institute for history of the medicine of the Robert Bosch foundation in Stuttgart. But nothing positive for the homoeopathy came of the government-supported examinations. Double blinded experiments were carried out with Silicea C30, for example. The result: Verum and placebo caused equal much symptoms. It was not possible for the homoeopaths present to distinguish verum and placebo. In 1938/39 clinical attempts with homeopathics were also accomplished with negative results in the Robert Koch hospital in Berlin. The homoeopath Rabe reacted with the assumption that [...] homoeopathy is no pharmacotherapeutic method, as assumed till now, but a form of psychotherapy [...]. Fritz Donner in a memory protocol: Truthfully one would have to answer that during the medicine examination nothing came out and that a reaction speaking for a therapeutical effect of the used medicines never has occurred in the clinical tests with a patient. Nevertheless it was announced officially that certain difficulties would have manifested themselves so that one must start newly. The war prevented however further research. Donner expressed himself more considerably later within the 1960s: He called the examination a total fiasco for the homoeopathy.