Andrew Wakefield

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Andrew Jeremy Wakefield (born 1957) is a British surgeon who received a lot of attention with a 1998 publication in The Lancet, both among experts and in public. The article titled Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children[1] correlates MMR vaccination with autism. As a consequence, vaccination rates dropped, especially in Great Britain.

In 2004, it became public that Wakefield had received 55,000 £ from lawyers representing parents of autistic children prior to the publication of his article.[2]. Lawyers were looking for connections between autism and vaccination in order to sue manufacturers of vaccines. This was known neither to Wakefield's co-authors nor to The Lancet. As a consequence, ten of thirteen authors stepped back.[3] In February 2010, the article was retracted by The Lancet.[4]

Wakefield resigned from his position in the Royal Free Hospital in London 2001, and now works for a private hospital in the USA. In 2007, he had to face charges by the British Medical Association.[5]In May 2010 he received an occupational ban[6].

His long refuted theories nonetheless are still accepted by esoteric or CAM inspired circles and persons, e.g. Christopher Maloney.

The Lancet article in 1998

In February 1998, a group around Andrew Wakefield published a report titled "Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children" in the renowned medical publication The Lancet.[1] The report analysed the cases of twelve autistic children who were treated in the Royal Free Hospital in the north of London in 1996-1997. The report described bowel related symptoms which, according to Wakefield, were to be seen as proof of a completely new syndrome which he later called Autistic Enterocolitis. Wakefield recommended a closer investigation of possible causes in the environment of these children, so e.g. in respect to the MMR vaccine. The publication suggested a connection between stomach-bowel symptoms and developmental disorders found in these children which was perceived as ostensibly related to the MMR vaccination. A causal connection of MMR vaccines leading to autism, however, was not established. In a press conference prior to the publication, Wakefield said he recommended the use of single vaccines instead of the triple MMR until clarification was obtained. He further stated that eight of the twelve parents considered the vaccination a possible cause, as vaccination and first symptoms occured within days. He stated he could not support the further use of MMR vaccine without detailed investigation. In a video recording prepared for TV in advance he demanded to stop the use of MMR and replace them with single vaccines instead.[7]

The resulting dispute

Report, press conference, and video unsettled the Britisch public. A heated debate followed, in which both sides used Wakefield's research as arguments. He was publicly criticized, with his critics expressing doubts regarding correctness as well as ethics of his research. Government and National Health Service (NHS) emphasized that extensive epidemiological data showed no correlation between MMR vaccination and developmental disorders. Many parents refused to believe this, since official information had been discredited earlier, as in the case of BSE. Government was accused that their true motif for rejecting single vaccinations was the higher cost of these. As a result, MMR vaccination rates decreased from 92% (1996) to 84% (2002). It was suspected that only 60% of neccessary MMR vaccinations were performed in some districts of London which is substantially below what is needed for herd immunity of measles. Although no measles epidemic occured so far, physicians warned that epidemics were possible since the number of infections was increasing.

One issue in the dispute was that only the combined vaccine is available via NHS. Parents rejecting this vaccine can either pay for single vaccinations out of their own pockets or not vaccinate at all. Then Prime Minister Tony Blair üublically defended the MMR vaccine, but at the same time refused to comment the vaccination status of his youngest son Leo.

The majority of pediatricians prefer the combined vaccine, as it is less strenuous for the child, and many parents rather have one vaccination done instead of three.

Epidemiological research on hundreds of thousands of children in numerous studies failed to indicate a link between MMR vaccination and autism. Critics of these studies, like the retired intern John Walker-Smith, despite being in support of the triple vaccine, labelled epidemiology a 'blunt tool' which does not neccesarily expose such connections.[8] As an example, it is difficult to find to populations differing in vaccination only.

Dr. Wakefield gave up his position at the Royal Free Hospital in 2001 and now works for a controversial private hospital in the USA. His continued studies include research on possible immunological, metabolical, and pathological changes caused by "Autistic Enterocolitis", as well as connections between bowel diseases and neurological disorders in children and their possible connection to vaccines[9]

Conflict of interest

In February 2004, journalist Brian Deer exposed information that Wakefield had recieved £ 55.000 in third-party funds prior to publishing the Lancet report, with the money paid by lawyers looking for a connection between autism and MMR vaccination.[10] According to the Sunday Times, several of the parents quoted were involved in law suits against manufacturers of MMR vaccines. Although Wakefield stated that these third-party funds had been public from the beginning, the fact that this was known neither to the Lancet nor to his co-authors raised much criticism. On February 20, 2004, the Lancet rated Wakefield's study flawed due to a fatal conflict of interest and concluded it should have never been published. Several of Wakefield's co-authors also criticized the lack of information about these third-party funds in explicit ways.[11] The General Medical Council, responsible for issuing medical licences and surveillance of medical ethics in Great Britain, began investigations.[12]

Furthermore, nine months before the incriminated report caused world-wide anxiety and uncertainty regarding the MMR vaccines, a series of patents protecting several potentially very profitable products happened to be submitted by Wakefield and the Royal Free Hospital Medical School in London. Obviously, such products would enjoy a much larger chance on the market if and when the MMR vaccines experienced a damage in reputation. The patents regarded an allegedly safe measles vaccine and medication for the treatment of bowel diseases and autism which were based on the assumption these conditions were caused by MMR vaccination.[13]

Lancet report retracted

As a consequence of Brian Deer's article, ten of altogether thirteen authors of the report formally renounced the claim of having found a connection between autism and MMR.[14] Deer continued investigations in a documentation on British TV titled MMR: What They Didn't Tell You, which was broadcast Nov. 18, 2004. The report accused Wakefield of owning patents on products competitive to MMR, and of being aware of test results from his own laboratories in contradiction to his claims.[15] On February 2, 2010, The Lancet announced to have the 1998 article removed completely from their list of publications.[4][16]

Anti-Vaccination lawyers paid 3.5 million Pound

Further investigation by the English newspaper Sunday Times established that Wakefield and others, prior to the publication, received up to 3.5 million British Pound from a law firm which represented the parents of children allegedly affected. Andrew Wakefield apparently received 500,000 pound, with first payments already having been made two years prior to the publication. Five of Wakefield's co-authors and one reviewer who checked the publication for The Lancet had also received personal payments. [17]

As a consequence, the Gerneral Medical Council prepared legal steps to have Wakefield's medical licence revoked.[18]

New studies on autism

Epidemiological research shows an upward trend for autism in recent years. The cause is uncertain; however, a change in diagnostics and census is more likely than an increase in actual numbers.[19][20][21] Diagnosis of autism has intensified in recent years, with children being examined more efficiently and at an earlier age than before. A causal link between MMR and autism can be excluded with utmost probability, as is shown by later studies which also happen to be very comprehensive in comparison to Wakefield's. Science today assumes that the different forms of autism are very much controlled by genetic factors. The importance of genetics in this field is emphasized by studies including twins: Whereas identical twins show a correlation of 80% to 90%, this risk is much lower for fraternal twins.

  • After Wakefields publication, many studies on MMR and autism followed. [22] In October 2003, a EU-funded meta-study was published, reviewing the results of 120 previous studies, summarizing and analyzing the adverse effects of MMR-vaccine[23]. The authors concluded:
    • The vaccine has both positive and adverse effects
    • A connection between MMR and autism is highly unlikely
    • Design and report of results relevant for security in MMR vaccine studies are mostly inadequate
  • In January 2005, after intensive research in Minnesota, an eightfold increase in autism was observed. Research covered a time span from the early 1980ies to the late 1990ies. No connection to MMR was found. Authors suspect that a change in both diagnostics and definition is responsible for this increase.[21]
  • In March 2005, a study on 30,000 children born near Yokohama concluded that autism is on the rise (from 46-86 cases in 10,000 children to 97-161 cases in 10,000 children), despite the fact that MMR vaccines were no longer used in Japan since April 1993. The authors concluded "The relevance of these results is that MMR is most likely not a cause of ASD, as the rise in ASD cannot be explained, and a withdrawal of MMR in countries where it is still in use will not lead to a decline in ASD.".[24] Wakefield claims, however, the rise in autism backed by data supported his hypothesis.[25] His point of view was met with little support, however.[26]
  • In October 2005, the Cochrane Library published a summary of scientific studies and concluded: "There is no plausible proof for the harmfullnes of MMR vaccine". On the other hand, these authors, too, criticized the design and the reporting of security-relevant results in MMR studies as mostly inadequate.[27] Cochrane - situated in Oxford, England - is seen as the highest independent control for medical publications and as a guardian of evidence-based medicine by many scientists.
  • A case-control study dated 2008 renders a connection between MMR and autism highly improbable.[28]

Revocation of medical licence

In May 2010, Wakefield lost his medical licence for Great Britain due to inappropriate conduct. The General Medical Council did not review the scientific basis for his research, but its realization. One issue was that Wakefield e.g. included a blood sample obtained from a friend of his son's using his son's birth date, and Wakefield also made a payment for the sample. The Council stated this was not in accordance with an appropriate conduct and caused damage to the medical profession.

Wakefield migrated to the USA where he founded a non-profit autism center in 2005. Despite the occupational ban in Great Britain he can practise medicine legally in the USA.[6].

Literature

  • Parker, S.J., Schwartz, B., Todd, J., and L.K. Pickering. 2004. Thimerosal-Containing Vaccines and Autistic Spectrum Disorder: A Critical Review of Published Original Data. Pediatrics, 114(3): Seiten 793-804

Weblinks

Quellennachweise

  1. ↑ 1.0 1.1 Wakefield AJ et al.: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet. 351(9103), 1998, S. 637-41 PMID 9500320 (PDF, 592 kB) Cite error: Invalid <ref> tag; name "Wakefield98" defined multiple times with different content
  2. ↑ Brian Deer: Revealed: MMR Research Scandal The Sunday Times (London) February 22 2004
  3. ↑ Murch SH et al.: Retraction of an interpretation. Lancet. 2004;363(9411):750 PMID 15016483
  4. ↑ 4.0 4.1 The Editors of The Lancet: Retraction – Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. The Lancet, Early Online Publication, 2 February 2010. doi:10.1016/S0140-6736(10)60175-7
  5. ↑ Reiner Luyken: Panik vor dem Piks. DIE ZEIT, 19.04.2007, 17/2007
  6. ↑ 6.0 6.1 http://www.spiegel.de/wissenschaft/medizin/0,1518,696472,00.html
  7. ↑ Video des Wakefield-Interviews
  8. ↑ http://www.vaccinationnews.com/DailyNews/February2002/AutBowMeas.htm
  9. ↑ A. Wakefield at his new employer
  10. ↑ B Deer: Revealed: MMR Research Scandal. The Sunday Times, London, February 22, 2004
  11. ↑ [1]
  12. ↑ [2]
  13. ↑ http://briandeer.com/wakefield-deer.htm
  14. ↑ Murch SH et al.: Retraction of an interpretation. Lancet. 2004;363(9411):750 PMID 15016483
  15. ↑ B Deer: Further accusations
  16. ↑ http://news.bbc.co.uk/2/hi/health/8493753.stm Lancet accepts MMR study 'false'
  17. ↑ H. Kaulen: Artikel in der FAZ, 8. Januar 2007
  18. ↑ Reiner Luyken: Panik vor dem Piks. Die Zeit, 19. April 2007, Nr. 17
  19. ↑ B Taylor et al.: Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. British Medical Journal, Vol 324, Feb. 16 2002, p. 393-396 PDF
  20. ↑ BMJJournals.com - 'Rapid Responses to: Increase in autism due to change in definition, not MMR vaccine' British Medical Journal (Meinungsaustausch der BMJ-Website)
  21. ↑ 21.0 21.1 WJ Barbaresi et al.: The incidence of autism in Olmsted County, Minnesota, 1976-1997: results from a population-based study. Arch Pediatr Adolesc Med. Jan. 2005, 159(1), p. 37-44 PMID 15630056
  22. ↑ List of 17 studies on a MMR-Autism link, Immunization Action Coalition [3]
  23. ↑ T Jefferson: Unintended events following immunization with MMR: a systematic review. Vaccine. 2003 Sep 8;21(25-26), p. 3954-60 PMID 12922131
  24. ↑ H Honda, Y Shimizu, M Rutter: No effect of MMR withdrawal on the incidence of autism: a total population study. J Child Psychol Psychiatry. 2005 Jun;46(6):572-9. PMID 15877763
  25. ↑ Japanese Study Is The Strongest Evidence Yet For A Link Between MMR And Autism. The Red Flag, March 6, 2005 [4]
  26. ↑ I Sample: Lingering fears of MMR-autism link dispelled. The Guardian, 3. März 2005 [5]
  27. ↑ V Demicheli,T Jefferson, A Rivetti, D Price: Vaccines for measles, mumps and rubella in children. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD004407. PDF
  28. ↑ Hornig M, Briese T, Buie T, Bauman ML, Lauwers G, et al. 2008 Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study. PLoS ONE 3(9): e3140 doi:10.1371/journal.pone.0003140 


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