Änderungen

Hinweise auf Nebenwirkungen zeigen sich in der erwähnten Studie zur Behandlung atopischer Dermatitis im British Journal of Dermatology aus dem Jahr 2004, und dies trotz der relativ kurzen Anwendung die unterhalb der üblichen Behandlungsdauer liegt. Die Gesamtzahl der Probanden war&nbsp;49. In der Arbeit ist zu lesen: ''Altogether 33&nbsp;cutaneous adverse events were recorded, and none of these was serious (Table&nbsp;3). [...] With the exception of one cutaneous adverse event (weeping, itching, limited neck mobility following application of the placebo cream, moderate severity), all were of mild severity. In two cases a possible and in four cases a probable relationship with the trial medication was assumed for the skin irritations occurred only on the body side treated with vitamin&nbsp;B12 cream (burning in two patients, itching in two patients, redness in one and hyperthermia and formication in one patient). All adverse events were reversible within several days. No acneiform eruptions were reported.''. Demnach brachen drei Patienten die Behandlung wegen Verschlechterung der Symptomatik und zwei wegen der Nebenwirkungen die experimentelle Behandlung ab. Zitat zu withdrawals ''Noncompliance&nbsp;3. Deterioration of disease&nbsp;3. Adverse events&nbsp;2, one patient experienced burning, itching and swelling one patient experienced redness and swelling'' (gekürzt).<ref>Stücker M; Pieck C; Stoerb C; Niedner R; Hartung J; Altmeyer P (2004): Topical vitamin B12 – a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Br J Dermatol 150, 977-983</ref>

Hinweise auf Nebenwirkungen zeigen sich in der erwähnten Studie zur Behandlung atopischer Dermatitis im British Journal of Dermatology aus dem Jahr 2004, und dies trotz der relativ kurzen Anwendung die unterhalb der üblichen Behandlungsdauer liegt. Die Gesamtzahl der Probanden war&nbsp;49. In der Arbeit ist zu lesen: ''Altogether 33&nbsp;cutaneous adverse events were recorded, and none of these was serious (Table&nbsp;3). [...] With the exception of one cutaneous adverse event (weeping, itching, limited neck mobility following application of the placebo cream, moderate severity), all were of mild severity. In two cases a possible and in four cases a probable relationship with the trial medication was assumed for the skin irritations occurred only on the body side treated with vitamin&nbsp;B12 cream (burning in two patients, itching in two patients, redness in one and hyperthermia and formication in one patient). All adverse events were reversible within several days. No acneiform eruptions were reported.''. Demnach brachen drei Patienten die Behandlung wegen Verschlechterung der Symptomatik und zwei wegen der Nebenwirkungen die experimentelle Behandlung ab. Zitat zu withdrawals ''Noncompliance&nbsp;3. Deterioration of disease&nbsp;3. Adverse events&nbsp;2, one patient experienced burning, itching and swelling one patient experienced redness and swelling'' (gekürzt).<ref>Stücker M; Pieck C; Stoerb C; Niedner R; Hartung J; Altmeyer P (2004): Topical vitamin B12 – a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. Br J Dermatol 150, 977-983</ref>

Prinzipiell besteht bei Anwendung von Vitamin B12 die Möglichkeit einer allergischen Reaktion<ref>Rodriguez, A. et al., ''Occupational contact allergy to vitamin B12.'' Journal of Allergy and Clinical Immunology.  Vol. 89, no. 1 part 2, S. 329. (1992)</ref><ref>Kleinschmidt, F. et Hogan, L., ''Allergic reaction to a vitamin B12 preparaton.'' Drug Intelligence and Clinical Pharmacy. Vol. 14, Seiten 716-717. (1980)</ref>.

Prinzipiell besteht bei Anwendung von Vitamin&nbsp;B12 die Möglichkeit einer allergischen Reaktion.<ref>Rodriguez, A. et al., ''Occupational contact allergy to vitamin B12.'' Journal of Allergy and Clinical Immunology.  Vol. 89, no. 1 part 2, S. 329. (1992)</ref><ref>Kleinschmidt, F. et Hogan, L., ''Allergic reaction to a vitamin B12 preparaton.'' Drug Intelligence and Clinical Pharmacy. Vol. 14, Seiten 716-717. (1980)</ref>

==Vermarktungsstrategie==

==Vermarktungsstrategie==