Änderungen

Die französische Zeitung ''Le Nouvel Observateur'' berichtete, dass die Autoren offenbar aus Angst vor der Chemieindustrie während der Laufzeit der Studie nicht miteinander telefonierten und im Nachrichtenaustausch Decknamen nutzten.

Die französische Zeitung ''Le Nouvel Observateur'' berichtete, dass die Autoren offenbar aus Angst vor der Chemieindustrie während der Laufzeit der Studie nicht miteinander telefonierten und im Nachrichtenaustausch Decknamen nutzten.

Mehrere Studien widerlegten in Folge die Angaben von Gilles-Éric Séralini über angeblich krebsauslösenden GMO-Mais MON810. Zu nennen sind drei GRACE-Studien (EU 7th Framework Programme project GRACE, 2014 bis 2018)<ref>Dagmar Zeljenková, Katarína Ambrušová, Mária Bartušová, Anton Kebis, Jevgenij Kovrižnych, Zora Krivošíková, Miroslava Kuricová, Aurélia Líšková, Eva Rollerová, Viera Spustová, Elena Szabová, Jana Tulinská, Soňa Wimmerová, Mikuláš Levkut, Viera Révajová, Zuzana Ševčíková, Kerstin Schmidt, Jörg Schmidtke, Jose Luis La Paz, Maria Corujo, Maria Pla, Gijs A Kleter, Esther J Kok, Jutta Sharbati, Carlos Hanisch, Ralf Einspanier, Karine Adel-Patient, Jean-Michel Wal, Armin Spök, Annette Pöting, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Pablo Steinberg: "Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)", Arch Toxicol, 88(12):2289-314, Oktober 2014, PMID: 25270621 PMCID: PMC4247492 DOI: 10.1007/s00204-014-1374-8<br>'' In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event.''</ref><ref>Dagmar Zeljenková, Radka Aláčová, Júlia Ondrejková, Katarína Ambrušová, Mária Bartušová, Anton Kebis, Jevgenij Kovrižnych, Eva Rollerová, Elena Szabová, Soňa Wimmerová, Martin Černák, Zora Krivošíková, Miroslava Kuricová, Aurélia Líšková, Viera Spustová, Jana Tulinská, Mikuláš Levkut, Viera Révajová, Zuzana Ševčíková 3, Kerstin Schmidt, Jörg Schmidtke, Paul Schmidt, Jose Luis La Paz, Maria Corujo, Maria Pla, Gijs A Kleter, Esther J Kok, Jutta Sharbati, Marc Bohmer, Nils Bohmer, Ralf Einspanier, Karine Adel-Patient, Armin Spök, Annette Pöting, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Pablo Steinberg: One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE, Arch Toxicol 20.7.2016, 90(10):2531-62. PMID: 27439414 PMCID: PMC5043003 DOI: 10.1007/s00204-016-1798-4<br>''..A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure.''</ref><ref>Jana Tulinská, Karine Adel-Patient, Hervé Bernard, Aurélia Líšková, Miroslava Kuricová, Silvia Ilavská, Mira Horváthová, Anton Kebis, Eva Rollerová, Júlia Babincová, Radka Aláčová, Jean-Michel Wal, Kerstin Schmidt, Jörg Schmidtke, Paul Schmidt, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Pablo Steinberg: Humoral and cellular immune response in Wistar Han RCC rats fed two genetically modified maize MON810 varieties for 90 days (EU 7th Framework Programme project GRACE), Arch Toxicol Juli 2018, 92(7):2385-2399. PMID: 29855658 PMCID: PMC6015625 DOI: 10.1007/s00204-018-2230-z</ref> und G-TwYST research consortium Studie 2019<ref>Pablo Steinberg et al., Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats. (mit erratum 2020), Arch Toxicol. Mai 2019 94(5):1779-1781. doi: 10.1007/s00204-019-02400-1. PMID: 30756133 PMCID: PMC7261740<br>''In 2012, a controversial study on the long-term toxicity of a Roundup herbicide and the glyphosate-tolerant genetically modified (GM) maize NK603 was published. The EC-funded G-TwYST research consortium tested the potential subchronic and chronic toxicity as well as the carcinogenicity of the glyphosate-resistant genetically modified maize NK603 by performing two 90-day feeding trials, one with GM maize inclusion rates of 11 and 33% and one with inclusion rates of up to 50%, as well as a 2-year feeding trial with inclusion rates of 11 and 33% in male and female Wistar Han RCC rats by taking into account OECD Guidelines for the testing of chemicals and EFSA recommendations on the safety testing of whole-food/feed in laboratory animals. In all three trials, the NK603 maize, untreated and treated once with Roundup during its cultivation, and the conventional counterpart were tested. Differences between each test group and the control group were evaluated. Equivalence was assessed by comparing the observed difference to differences between non-GM reference groups in previous studies. In case of significant differences, whether the effects were dose-related and/or accompanied by changes in related parameters including histopathological findings was evaluated. It is concluded that no adverse effects related to the feeding of the NK603 maize cultivated with or without Roundup for up to 2 years were observed. Based on the outcome of the subchronic and combined chronic toxicity/carcinogenicity studies, recommendations on the scientific justification and added value of long-term feeding trials in the GM plant risk assessment process are presented.''</ref>

Mehrere Studien widerlegten in Folge die Angaben von Gilles-Éric Séralini über angeblich krebsauslösenden GMO-Mais MON810<ref>https://allianceforscience.org/blog/2018/06/european-studies-disprove-seralinis-gmo-maize-tumor-claims/</ref>. Zu nennen sind drei GRACE-Studien (EU 7th Framework Programme project GRACE, 2014 bis 2018)<ref>Dagmar Zeljenková, Katarína Ambrušová, Mária Bartušová, Anton Kebis, Jevgenij Kovrižnych, Zora Krivošíková, Miroslava Kuricová, Aurélia Líšková, Eva Rollerová, Viera Spustová, Elena Szabová, Jana Tulinská, Soňa Wimmerová, Mikuláš Levkut, Viera Révajová, Zuzana Ševčíková, Kerstin Schmidt, Jörg Schmidtke, Jose Luis La Paz, Maria Corujo, Maria Pla, Gijs A Kleter, Esther J Kok, Jutta Sharbati, Carlos Hanisch, Ralf Einspanier, Karine Adel-Patient, Jean-Michel Wal, Armin Spök, Annette Pöting, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Pablo Steinberg: "Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)", Arch Toxicol, 88(12):2289-314, Oktober 2014, PMID: 25270621 PMCID: PMC4247492 DOI: 10.1007/s00204-014-1374-8<br>'' In the present study, the results of two 90-day feeding trials with two different GM maize MON810 varieties, their near-isogenic non-GM varieties and four additional conventional maize varieties are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 408. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after subchronic exposure, independently of the two different genetic backgrounds of the event.''</ref><ref>Dagmar Zeljenková, Radka Aláčová, Júlia Ondrejková, Katarína Ambrušová, Mária Bartušová, Anton Kebis, Jevgenij Kovrižnych, Eva Rollerová, Elena Szabová, Soňa Wimmerová, Martin Černák, Zora Krivošíková, Miroslava Kuricová, Aurélia Líšková, Viera Spustová, Jana Tulinská, Mikuláš Levkut, Viera Révajová, Zuzana Ševčíková 3, Kerstin Schmidt, Jörg Schmidtke, Paul Schmidt, Jose Luis La Paz, Maria Corujo, Maria Pla, Gijs A Kleter, Esther J Kok, Jutta Sharbati, Marc Bohmer, Nils Bohmer, Ralf Einspanier, Karine Adel-Patient, Armin Spök, Annette Pöting, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Pablo Steinberg: One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE, Arch Toxicol 20.7.2016, 90(10):2531-62. PMID: 27439414 PMCID: PMC5043003 DOI: 10.1007/s00204-016-1798-4<br>''..A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure.''</ref><ref>Jana Tulinská, Karine Adel-Patient, Hervé Bernard, Aurélia Líšková, Miroslava Kuricová, Silvia Ilavská, Mira Horváthová, Anton Kebis, Eva Rollerová, Júlia Babincová, Radka Aláčová, Jean-Michel Wal, Kerstin Schmidt, Jörg Schmidtke, Paul Schmidt, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Pablo Steinberg: Humoral and cellular immune response in Wistar Han RCC rats fed two genetically modified maize MON810 varieties for 90 days (EU 7th Framework Programme project GRACE), Arch Toxicol Juli 2018, 92(7):2385-2399. PMID: 29855658 PMCID: PMC6015625 DOI: 10.1007/s00204-018-2230-z</ref> und G-TwYST research consortium Studie 2019<ref>Pablo Steinberg et al., Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats. (mit erratum 2020), Arch Toxicol. Mai 2019 94(5):1779-1781. doi: 10.1007/s00204-019-02400-1. PMID: 30756133 PMCID: PMC7261740<br>''In 2012, a controversial study on the long-term toxicity of a Roundup herbicide and the glyphosate-tolerant genetically modified (GM) maize NK603 was published. The EC-funded G-TwYST research consortium tested the potential subchronic and chronic toxicity as well as the carcinogenicity of the glyphosate-resistant genetically modified maize NK603 by performing two 90-day feeding trials, one with GM maize inclusion rates of 11 and 33% and one with inclusion rates of up to 50%, as well as a 2-year feeding trial with inclusion rates of 11 and 33% in male and female Wistar Han RCC rats by taking into account OECD Guidelines for the testing of chemicals and EFSA recommendations on the safety testing of whole-food/feed in laboratory animals. In all three trials, the NK603 maize, untreated and treated once with Roundup during its cultivation, and the conventional counterpart were tested. Differences between each test group and the control group were evaluated. Equivalence was assessed by comparing the observed difference to differences between non-GM reference groups in previous studies. In case of significant differences, whether the effects were dose-related and/or accompanied by changes in related parameters including histopathological findings was evaluated. It is concluded that no adverse effects related to the feeding of the NK603 maize cultivated with or without Roundup for up to 2 years were observed. Based on the outcome of the subchronic and combined chronic toxicity/carcinogenicity studies, recommendations on the scientific justification and added value of long-term feeding trials in the GM plant risk assessment process are presented.''</ref>

Zeitgleich zur Aufsehen erregenden Studie (auch in Deutschland<ref>http://www.welt.de/gesundheit/article109325059/Mit-Genmais-gefuetterte-Ratten-sterben-viel-frueher.html</ref><ref>http://www.spiegel.de/wissenschaft/natur/gentechnik-studie-entfacht-debatte-um-monsanto-mais-a-856823.html</ref><ref>http://www.taz.de/Genmais-und-Rattenkrebs/!102051/</ref><ref>http://www.augsburger-allgemeine.de/wissenschaft/Genmais-Futter-kann-Ratten-schwer-krank-machen-Leberschaeden-Tumore-Nierenschaeden-id21983386.html</ref><ref>http://www.n-tv.de/politik/Genmais-verursacht-Tumore-article7267191.html</ref>) veröffentlichte Séralini ein Buch mit dem Titel ''Tous Cobayes?'' (deutsch: ''Sind wir [alle] Versuchskaninchen?'') zum selben Thema, was in der Fachwelt für Verwunderung und Empörung sorgte, da der Buchabsatz von der gleichzeitigen, öffentlichen Diskussion über die Studie profitierte.

Zeitgleich zur Aufsehen erregenden Studie (auch in Deutschland<ref>http://www.welt.de/gesundheit/article109325059/Mit-Genmais-gefuetterte-Ratten-sterben-viel-frueher.html</ref><ref>http://www.spiegel.de/wissenschaft/natur/gentechnik-studie-entfacht-debatte-um-monsanto-mais-a-856823.html</ref><ref>http://www.taz.de/Genmais-und-Rattenkrebs/!102051/</ref><ref>http://www.augsburger-allgemeine.de/wissenschaft/Genmais-Futter-kann-Ratten-schwer-krank-machen-Leberschaeden-Tumore-Nierenschaeden-id21983386.html</ref><ref>http://www.n-tv.de/politik/Genmais-verursacht-Tumore-article7267191.html</ref>) veröffentlichte Séralini ein Buch mit dem Titel ''Tous Cobayes?'' (deutsch: ''Sind wir [alle] Versuchskaninchen?'') zum selben Thema, was in der Fachwelt für Verwunderung und Empörung sorgte, da der Buchabsatz von der gleichzeitigen, öffentlichen Diskussion über die Studie profitierte.