Änderungen

Strategy: In the case of corona viruses spike glycoprotein, which is first to attach to host cell membrane, initiating the infection, is the most relevant target for design of vaccine. To be able to design a universal vaccine for all corona viruses, we will identify a common characteristic parameter for spike proteins from different strains and then use this parameter for vaccine design.

Strategy: In the case of corona viruses spike glycoprotein, which is first to attach to host cell membrane, initiating the infection, is the most relevant target for design of vaccine. To be able to design a universal vaccine for all corona viruses, we will identify a common characteristic parameter for spike proteins from different strains and then use this parameter for vaccine design.

For that purpose, we will utilize the Resonant Recognition Model (RRM), which proposes that protein biological function is characterized by certain periodicities (frequencies) within distribution of free electron energies along protein. The RRM is capable of identifying common

For that purpose, we will utilize the Resonant Recognition Model (RRM), which proposes that protein biological function is characterized by certain periodicities (frequencies) within distribution of free electron energies along protein. The RRM is capable of identifying common

characteristics for proteins having the same biological function/interaction, but not necessarily having high level of homology. We have previously successfully utilized the RRM model in analysis of HIV virus, where we have identified common RRM characteristic for all different and very variable strains of HIV virus. Based on this characteristic we have designed and experimentally tested peptides that will be used in universal vaccine for all HIV strains.<br>

characteristics for proteins having the same biological function/interaction, but not necessarily having high level of homology. We have previously successfully utilized the RRM model in analysis of HIV virus, where we have identified common RRM characteristic for all different and very variable strains of HIV virus. Based on this characteristic we have designed and experimentally tested peptides that will be used in universal vaccine for all HIV strains.

 

COR 19: Corona viruses are retroviruses, enveloped viruses with positive-sense single-stranded RNA genome, which is the largest among known RNA viruses. The retrovirus is a type of RNA virus that inserts a copy of its genome into the DNA of a host cell that it invades, thus changing

COR 19: Corona viruses are retroviruses, enveloped viruses with positive-sense single-stranded RNA genome, which is the largest among known RNA viruses. The retrovirus is a type of RNA virus that inserts a copy of its genome into the DNA of a host cell that it invades, thus changing

the genome of that cell. In most viruses, DNA is transcribed into RNA, and then RNA is translated into protein. However, retroviruses function differently, as their RNA is reverse transcribed into DNA and integrated into the host cell's genome (when it becomes a provirus), and then undergoes the usual transcription and translational processes to express the genes carried by the virus. The information contained in a retroviral gene is thus used to generate the corresponding protein via the sequence: RNA → DNA → RNA → polypeptide. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus.

the genome of that cell. In most viruses, DNA is transcribed into RNA, and then RNA is translated into protein. However, retroviruses function differently, as their RNA is reverse transcribed into DNA and integrated into the host cell's genome (when it becomes a provirus), and then undergoes the usual transcription and translational processes to express the genes carried by the virus. The information contained in a retroviral gene is thus used to generate the corresponding protein via the sequence: RNA → DNA → RNA → polypeptide. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus.